"Molecular dissection of autophagy: two ubiquitin-like systems". "A ubiquitin-like system mediates protein lipidation". Ichimura, Y Kirisako, T Takao, T Satomi, Y Shimonishi, Y Ishihara, N Mizushima, N Tanida, I Kominami, E Ohsumi, M Noda, T Ohsumi, Y (23 November 2000)."LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". Kabeya, Y Mizushima, N Ueno, T Yamamoto, A Kirisako, T Noda, T Kominami, E Ohsumi, Y Yoshimori, T (2000)."A protein conjugation system essential for autophagy". Mizushima, N Noda, T Yoshimori, T Tanaka, Y Ishii, T George, MD Klionsky, DJ Ohsumi, M Ohsumi, Y (24 September 1998)."Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae". Tsukada, M Ohsumi, Y (25 October 1993)."Ultrastructural Analysis of the Autophagic Process in Yeast: Detection of Autophagosomes and Their Characterization". PMID 1400575.įollow up with more research on yeast: "Autophagy in Yeast Demonstrated with Proteinase-Deficient Mutants and Conditions for Its Induction".
His original findings about autophagy in yeast cells: She is a co-author of many academic papers with him. Ohsumi's spouse Mariko, a Professor of Teikyo University of Science, collaborated on his research. He is the 25th Japanese person to be awarded a Nobel Prize. In 2016, he was awarded the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy". During the 1990s, Ohsumi's group described the morphology of autophagy in yeast, and performed mutational screening on yeast cells that identified essential genes for cells to be capable of autophagy. Prior to that time, less than 20 papers per year were published on this subject. Ĭhristian de Duve coined the term autophagy in 1963 whereas Ohsumi began his work in 1988. Currently, he is head of the Cell Biology Research Unit, Institute of Innovative Research, Tokyo Institute of Technology. After his retirement in 2014, he continued to serve as Professor at Institute of Innovative Research, Tokyo Institute of Technology. In 2009 he transitioned to a three-way appointment as an emeritus professor at the National Institute for Basic Biology and at the Graduate University for Advanced Studies, and a professorship at the Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology (Tokyo Tech). From 2004 to 2009 he was also professor at the Graduate University for Advanced Studies in Hayama, Japan. In 1996 he moved to the National Institute for Basic Biology, Japan in Okazaki City, Japan. He returned to the University of Tokyo in 1977 as a research associate he was appointed Lecturer there in 1986, and promoted to Associate Professor in 1988. In 1974–77 he was a postdoctoral fellow at the Rockefeller University in New York City. in 1974, both from the University of Tokyo. Ohsumi was born on February 9, 1945, in Fukuoka, Japan.